A general course on methods and applications of genetic analysis. Topics include genetic variation, cytogenetics, gene inheritance, gene mapping, gene function, quantitative genetics, population genetics and evolution, cell and developmental biology.
Aspects of genetics that are important in human biology. Topics include chromosome abnormalities, genes and genetic disease, immunogenetics, cancer, ageing, complex traits, family studies and populations.
A general course on the principles and applications of genetics, with an emphasis on problem solving. Topics include gene structure, function and variation, genetic inheritance, cellular genetics and cytogenetics, population and quantitative genetics, genomics, and methods of genetic analysis.
DNA structure, topology and recombination. The contributions of bacteriophage to DNA technology. Advanced applications of DNA sequencing, gene cloning, PCR, microarrays and gene targeting, including molecular diagnostics of genetic disorders. Practical experience will be gained with DNA quantification, molecular cloning, PCR, DNA sequencing, molecular diagnostics of genetic disorders, computer analysis and expression of heterologous genes.
An advanced course in laboratory techniques used in Genetics. Emphasis is on understanding the theory behind the methods used, on data evaluation and on the application of genetic techniques to various questions in biology. Practicals include microarray analysis, transposon tagging, human microsatellite and SNP analysis and reporter gene expression.
A course with a strong emphasis on the structure and function of mammalian cells. Topics covered include chromosome structure and function, cell cycle, signal transduction, cytoskeleton and molecular motors, cell adhesions and interactions, cell motility, stem cells and their biomedical potential, cell death and cancer. The practical component has a strong emphasis on biochemical, genetic and microscopic methods that are used to study eukaryotic cells.
An interactive and self-directed learning approach will be used to explore the analysis of genomes, transcriptomes and metagenomes. The emphasis will be on understanding and applying a range of practical methodologies to extract biologically significant information from large genetic data sets.
A course on the advanced methods and applications of molecular biology. Topics include an historical overview, the contributions of bacteriophage to molecular biology, PCR, gene cloning, protein engineering, genomics, microarrays, forensics and synthetic biology. Practical experience will be gained with PCR, molecular cloning and DNA sequencing.
A course on understanding organisms at the level of the genome (the genes), the proteome (the proteins), and the population. Advances in understanding the structure, function, and evolution of the genome and proteome, with emphasis on model organisms, will be discussed. Genetic, biochemical, and evolutionary techniques used to dissect biological function will be described, as will the integration of that information to understand cellular and evolutionary processes.
Regulation of gene expression including chromatin structure, transcription factors, modulation of transcription (e.g. immunoglobulin genes) and post-transcriptional control mechanisms. Signal transduction, protein structure and function as it relates to proton pumps, catalytic strategies, translation and protein sorting. The structural organization of the cytoskeleton, knowledge of cell adhesion and the extracellular matrix, cell signalling mechanisms, cell cycles and vesicular transport.
An advanced course on using genetics and genomics to solve modern problems in biology. The course will explore how genetics and genomics data can be used to understand ancestry and health, and how genes interact with diet and drugs to produce variation. Students will investigate ethical and counselling issues related to personal genomic data. Genetic variation, with an emphasis on humans, will be described, alongside its use in forensics. The newfound role of RNA in regulating gene expression will be covered.
An advanced course based on current literature where genetic approaches are used to understand important biological processes. Topics will include DNA recombination, plant-microbe symbiosis, plant-fungal gene interactions, the genetic basis of learning and memory and epigenetics.