Rachel White

Doctor of Philosophy, (Chemistry)
Study Completed: 2010
College of Sciences

Citation

Thesis Title
Synthesis of cyclodextrin composites incorporating targeting and drug carrying capabilities

Read article at Massey Research Online: MRO icon

Ms White researched the attachment of bioactive peptides to cyclodextrin, a well recognised biologically acceptable molecule, to form a complex with potential use in drug delivery. Bioactive peptides are commonly associated with cellular processes and can be used for medicinal purposes. Sulfonamides were attached to cyclodextrin complexes using a process called solid phase peptide synthesis. This is a common technique, but one which has not been used for such synthetic applications. Ms White’s cyclodextrin compounds were biologically tested against cancer cell lines. The chemistry has paved the way for future advancements in both the chemistry and delivery mechanisms.

Supervisors
Professor David Harding
Associate Professor Paul Plieger

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